Gastroenterology

Gastroenterology

Volume 163, Issue 6, December 2022, Pages 1691-1694.e7
Gastroenterology

Research Letter
Noncoding Aberrations in Mismatch Repair Genes Underlie a Substantial Part of the Missing Heritability in Lynch Syndrome

https://doi.org/10.1053/j.gastro.2022.08.041Get rights and content
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Abbreviations used in this paper

dMMR
mismatch repair deficient
LS
Lynch syndrome
LLS
Lynch-like syndrome
MMR
mismatch repair
PV
pathogenic variant

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Author names in bold designate shared co-first authorship.

Conflicts of interest The authors disclose no conflicts.

Funding This project received funding from the Sacha Swarttouw-Hijmans Foundation. The Solve-RD project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 779257. This research is supported (not financially) by the European Reference Network on Genetic Tumor Risk Syndromes (ERN GENTURIS)—Project ID No. 739547 and the Dutch X-omics Initiative, which is partly funded by NWO (184.034.019). ERN GENTURIS is partly co-funded by the European Union within the framework of the Third Health Program ERN-2016 with Framework Partnership Agreement 2017–2021.